Nuclear DNA content in dimethylhydrazine-induced colonic carcinoma and mucosal dysplasia in rats
نویسندگان
چکیده
منابع مشابه
the effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولAtrazine in sub-acute exposure results in sperm DNA disintegrity and nuclear immaturity in rats
This study was designed to evaluate the detrimental effect of atrazine (ATR) on germinal epitheliums (GE) cytoplasmic carbohydrate (CH) and unsaturated fatty acids (UFA) ratio and to clarify the effect of ATR on serum levels of FSH, LH, testosterone and inhibin-B (INH-B). The impact of ATR exposure on total antioxidant capacity (TAC), sperm DNA packing and integrity were also investigated. Seve...
متن کاملEarly alterations in rat colonic mucosal cyclic nucleotide metabolism and protein kinase activity induced by 1,2-dimethylhydrazine.
The present study examined the acute effects of intrarectal administration of a single dose (25 mg/kg) of the colon carcin ogen 1,2-dimethylhydrazine (DMH) on DMA synthesis and cyclic nucleotide metabolism in rat colonie mucosa. DMH ini tially inhibited DMA synthesis (12 and 24 hr postinstillation) in distal colonie mucosa, at which time there were no detectable alterations in tissue cyclic ade...
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The clinicopathological details of eight cases of ulcerative colitis complicated by carcinoma of the colon are described. There was a total of 14 primary colonic cancers, six of which were not detected before pathological examination of the resection specimens. The reason for this may be related to atypical tumour growth patterns. Three occurred in flat mucosa, one in a mucosal plaque lesion, a...
متن کاملDysplasia-Carcinoma Transition Specific Transcripts in Colonic Biopsy Samples
BACKGROUND The early molecular detection of the dysplasia-carcinoma transition may enhance the strength of diagnosis in the case of colonic biopsies. Our aims were to identify characteristic transcript sets in order to develop diagnostic mRNA expression patterns for objective classification of benign and malignant colorectal diseases and to test the classificatory power of these markers on an i...
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ژورنال
عنوان ژورنال: Cancer
سال: 1984
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19840501)53:9<1918::aid-cncr2820530918>3.0.co;2-b